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elagolix
- Name elagolix
- CAS 834153-87-6
- Purity 99%
Product Details
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- Molecular Formula: C32H30 F5 N3 O5
- Molecular Weight: 631.599
- Boiling Point: 728.6±70.0 °C(Predicted)
- PKA: 4.40±0.10(Predicted)
- PSA： 102.56000
- Density: 1.350
- LogP: 5.92590
834153-87-6 Relevant articles
Synthetic method of elagolix
-
Page/Page column 7-11, (2019/06/11)
The invention discloses a synthetic meth...
Method for preparing intermediate of elagolix
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, (2019/12/09)
The invention relates to a method for pr...
Method for preparing agomelatine intermediate (by machine translation)
-
, (2019/12/09)
The invention relates to a method for pr...
Preparation method of Elagolix
-
Paragraph 0023-0035, (2019/05/02)
The invention discloses a preparation me...
834153-87-6 Process route
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![(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione](/upload/2026/11/168eb127d53a437e880bdf8bddb4ea8e_358bafcb-3736-4c03-a90f-92f05eacfdb9.png)
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(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
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![4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid](/upload/2026/11/0dd7f444200441949978b9c5af09daf7_e54ea82f-c3c2-4f97-9cbf-aefb7bfd9182.png)
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834153-87-6
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
| Conditions | Yield |
|---|---|
|
With
water; sodium hydroxide;
In
ethanol;
at 55 - 60 ℃;
|
89%
|
-
-
ethyl (R)-4-((tert-butoxycarbonyl)(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1-(2H)-yl)-1-phenylethyl)amino)butyrate
-
-
834153-87-6
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
| Conditions | Yield |
|---|---|
|
With
water; potassium carbonate;
In
tetrahydrofuran;
at 50 ℃;
for 6h;
Solvent;
Temperature;
|
82%
|
834153-87-6 Upstream products
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832720-84-0
4-((R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-yl]-1-phenylethylamino)butyric acid ethyl ester
-
1092070-97-7
methyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate
-
830346-50-4
3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate
-
1150560-59-0
5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
