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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
- Name (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
- CAS 85977-52-2
- Purity 99%
Product Details
Excellent chemical plant bulk supply (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
- Molecular Formula: C11H12O2
- Molecular Weight: 176.215
- Appearance/Colour: Crystalline white or yellow powder
- Vapor Pressure: 2.85E-05mmHg at 25°C
- Melting Point: 54-56 °C
- Refractive Index: 1.576
- Boiling Point: 342.7 °C at 760 mmHg
- PKA: 4.28±0.20(Predicted)
- Flash Point: 156.4 °C
- PSA： 37.30000
- Density: 1.186 g/cm3
- LogP: 2.19110
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid(Cas 85977-52-2) Usage
InChI:InChI=1/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)/t10-/m0/s1
85977-52-2 Relevant articles
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Paragraph 0093; 0102; 0103; 0104, (2018/08/04)
The invention discloses a preparation me...
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, (2018/03/13)
The invention relates to a preparation m...
Method for chiral preparation of (S)-tetrahydro-1-naphthoic acid and derivative thereof
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Paragraph 0020, (2017/12/28)
The invention relates to a method for ch...
Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one
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This invention relates to a process for ...
85977-52-2 Process route
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-
1914-65-4
tetralin-1-carboxylic acid
-
-
85977-52-2
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
quinine;
In
ethanol;
at 0 - 50 ℃;
for 0.5h;
|
43.6%
|
|
nach Abtrennung des Cinchonin-Salzes der (R)-1.2.3.4-Tetrahydro-naphthoesaeure-(1) (s.o.) ueber das Chinin-Salz;
|
|
|
Multi-step reaction
with
2
steps
1: water; ethanol / 2 h / Reflux
2: hydrogenchloride / water; ethyl acetate / 0.5 h
With
hydrogenchloride;
In
ethanol; water; ethyl acetate;
|
-
![(R)-[1-ethoxy-1-carbonylpropan-2-yl]-(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid ester](/upload/2026/10/e0e5dc04982c4e2f976b46cedd95fb59_c4b64720-2474-4279-80dc-42e20bcfc0e7.png)
-
(R)-[1-ethoxy-1-carbonylpropan-2-yl]-(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid ester
-
-
85977-52-2
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
Autoclave;
Green chemistry;
|
83%
|
85977-52-2 Upstream products
-
1914-65-4
tetralin-1-carboxylic acid
-
3123-46-4
4-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
-
86-55-5
1-naphthalenecarboxylic acid
85977-52-2 Downstream products
-
177793-79-2
N-(1-azabicyclo[2.2.2]oct-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide
-
1207325-89-0
C21 H23 NO3
-
1269634-46-9
C21 H22 ClNO3
-
135729-60-1
palonosetron
